Srijit Seal

Srijit Seal

Principal Scientist, Human Chemical Company
Visiting Researcher, Uppsala University

Drug discovery Artificial intelligence Scientific practice

Selected posts

Selected LinkedIn posts, with lifetime reactions and publication year.
Title
Artificial intelligence in drug discovery: where we stand

Our Perspective in Nature Reviews Drug Discovery on the current state of AI in the field.

Srijit Seal, Research
993
AI agents in drug discovery: a review with industry case studies

A collaboration between researchers, startups, and venture partners.

Srijit Seal, Research
503
Cell count as a bioactivity benchmark

Our Nature Communications paper on cell count, cytotoxicity, and benchmark design.

Srijit Seal, Research
400
Model validation for small-molecule drug discovery

The Polaris collaboration on testing whether models generalize to new chemistry.

Srijit Seal, Research
388
Cell Painting in primary human hepatocytes

Our Cell Systems paper on cytotoxicity and mode-of-action analysis.

Srijit Seal, Research
388
Evaluating LLM-generated benchmarks

Reflections on reviewing datasets and evaluations for NeurIPS.

Srijit Seal, Scientific practice
386
Reflections on my time at Merck

What I learned from colleagues across discovery science and computational toxicology.

Srijit Seal, Careers
340
Unrealistic experience requirements in AI jobs

A job asking for more years of PyTorch experience than PyTorch has existed.

Srijit Seal, Careers
334
Best Paper Award for toxicity prediction guidelines

Recognition from the SOT Regulatory and Safety Evaluation Specialty Section.

Srijit Seal, Research
332
Roles in cheminformatics, ADMET, and computational chemistry

A March 2026 collection of positions in pharma and biotech. Some roles may now be closed.

Srijit Seal, Careers
252
AI agents in drug discovery, published in Drug Discovery Today

The published review of applications and case studies from academia and industry.

Srijit Seal, Research
242
Cell Painting: a decade of discovery and innovation

Our Nature Methods review of the assay, its applications, and the community using it.

Srijit Seal, Research
225
Lessons from the OpenADMET PXR challenge

Using Codex while thinking through assay biology, validation, and activity cliffs.

Srijit Seal, AI
210
Fabricated references in scientific papers

Reference managers, DOI checks, and the responsibility to verify citations.

Srijit Seal, Scientific practice
187
An open reading link for our Cell Painting review

Sharing a free reading link and thanking the review's co-authors.

Srijit Seal, Research
179
An MPhil graduation at Clare Hall

Celebrating a postponed graduation ceremony and the support behind my research.

Srijit Seal, Careers
173
AI and computational chemistry job opportunities

An April 2026 collection of positions in pharma and biotech. Some roles may now be closed.

Srijit Seal, Careers
153
AI models for drug discovery

Models for liver toxicity, cardiotoxicity, cell imaging, and pharmacokinetics.

Srijit Seal, Research
138
When plate layout predicts toxicity

Why imaging models need comparisons against technical controls.

Srijit Seal, Scientific practice
115
arXiv policies for review articles

A discussion of preprint policies and concerns about LLM-generated submissions.

Srijit Seal, Scientific practice
109
BioMorph: interpreting Cell Painting features

Linking image-based profiling to biological measurements and sharing ML-ready datasets.

Srijit Seal, Research
104
Scientist salaries and working hours in biotech

Questions about pay and working-hour expectations in startup job postings.

Srijit Seal, Careers
89
Defining AI, LLM, and QSAR for scientific audiences

Late-night slide preparation and familiar requests from reviewers.

Srijit Seal, Scientific practice
79
Understanding Biology in the Age of Artificial Intelligence

Announcing the June 2023 conference at the University of Cambridge.

Srijit Seal, Events
70
The quality of scientific peer review

A reflection on factual errors in reviews and the use of AI by reviewers.

Srijit Seal, Scientific practice
68
What very small p values tell us

Statistical precision, model assumptions, and real-world sources of error.

Srijit Seal, Scientific practice
37
Scaling AI for drug discovery

Questions about the quality of future discoveries, as well as their number.

Srijit Seal, AI
36
Foundation models at the Cambridge Cheminformatics Meeting

An invitation to discuss foundation models for non-clinical safety.

Srijit Seal, Events
6